发表论文
(1) Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Rilei Yu*, Lu Z*. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells. Mol Cell. 2021 Jun 3;81(11):2303-2316.e8 （IF: 17.97）
(2) Li X, Tae HS, Chu Y, Jiang T, Adams DJ*, Rilei Yu*. Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor. Pharmacol Ther. 2021 Jun;222:107792. (IF:12.3)
(3) Jiazhen Liang, Han-Shen Tae, Xiaoxiao Xu, Tao Jiang, David J. Adams and Rilei Yu*. Dimerization of α-conotoxins as a strategy to enhance the inhibition of the human α7 and α9α10 nicotinic acetylcholine receptors. J. Med. Chem. 2020 Feb 26. doi: 10.1021/acs.jmedchem.9b01536. (IF:6.2)
(4) Rilei Yu*, Wang J, So LY, Harvey PJ, Shi J, Liang J, Dou Q, Li X, Yan X, Huang YH, Xu Q, Kaas Q, Chow HY, Wong KY, Craik DJ, Zhang X, Jiang T, Wang Y*. Enhanced Activity against Multi-drug Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway. J. Med. Chem. 2020 Jan 31. doi: 10.1021/acs.jmedchem.9b01563. (IF:6.2)
(5) Xin Chu, Han-Shen Tae, Qingliang Xu, Tao Jiang, David J. Adams and Rilei Yu. α-Conotoxin Vc1.1 Structure-Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement. ACS Chem. Neurosci. 2019, 10(10).
(6) Xu X, Liang J, Zhang Z, Jiang T, Yu R*. Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations. Mar. Drugs. 2019 May 23;17(5). pii: E303. doi: 10.3390/md17050303.
(7) Rilei Yu1,2*, Han-Shen Tae3, Qingliang Xu1,2, David J. Craik4, David J. Adams3, Tao Jiang1,2 and Quentin Kaas4*. An antagonist-bound structure of the human α4β2 nicotinic acetylcholine receptor. Br. J. Pharmacol. 2019 Aug;176(15):2750-2763. doi: 10.1111/bph.14698. Epub 2019 Jun 7.
(8) Rilei Yu*, Han-Shen Tae, Nargis Tabassum, Juan Shi, Tao Jiang, and David J. Adams*. Molecular determinants conferring the stoichiometric-dependent activity of α-conotoxins at the human α9α10 nicotinic acetylcholine receptor subtype. J. Med. Chem. May 7, 2018. DOI: 10.1021/acs.jmedchem.8b00115
(9) Fangling Chen, Wenxin Huang, Tao Jiang and Rilei Yu*. Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations. Mar. Drugs. 2018, 16(5), 153; https://doi.org/10.3390/md16050153
(10) Yujuan Han1, Rilei Yu1, Gao P, Xinzhi Lu*, Wengong Yu*. The hydrogen-bond network around Glu160 contributes to the structural stability of chitosanase CsnA from Renibacterium sp. QD1. Int. J. Biol. Macromol. 2017 Nov 18. pii: S0141-8130(17)33557-2. doi: 10.1016/j.ijbiomac.2017.11.071.
(11) Ma Q, Tae HS, Wu G, Jiang T, Yu, R*. Exploring the Relationship between Nicotinic Acetylcholine Receptor Ligand Size, Efficiency, Efficacy, and C-Loop Opening. J. Chem. Inf. Model. 2017 Aug 28;57(8):1947-1956. doi: 10.1021/acs.jcim.7b00152. Epub 2017 Aug 2
(12) Jiang, L.; Yin, R.; Wang, X.; Dai, J.; Li, J.; Jiang, T*.; Yu, R*. Design and Synthesis of Neolamellarin a Derivatives Targeting Heat Shock Protein 90. Eur. J. Med. Chem. 2017, 135, 24–33.
(13) Yu, R.; Seymour, V. A. L.; Berecki, G.; Jia, X.; Akcan, M.; Adams, D. J.; Kaas, Q.; Craik, D. J. Less Is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Sci. Rep. 2015, 5, 13264.
(14) Yu, R.; Hurdiss, E.; Greiner, T.; Lape, R.; Sivilotti, L.; Biggin, P. C. Agonist and Antagonist Binding in Human Glycine Receptors.Biochemistry (Mosc.) 2014, 53 (38), 6041–6051.
(15) Yu, R.; Kompella, S. N.; Adams, D. J.; Craik, D. J.; Kaas, Q. Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor. J. Med. Chem. 2013, 56 (9), 3557–3567.
(16) Yu, R.; Kaas, Q.; Craik, D. J. Delineation of the Unbinding Pathway of α-Conotoxin ImI from the α 7 Nicotinic Acetylcholine Receptor. J. Phys. Chem. B 2012, 116 (21), 6097–6105.
(17) Yu, R.; Craik, D. J.; Kaas, Q. Blockade of Neuronal α7-nAChR by α-Conotoxin ImI Explained by Computational Scanning and Energy Calculations. PLoS Comput. Biol. 2011, 7 (3), e1002011
申请专利
1.于日磊、史娟、江涛，一种氨基酸全部选用D型氨基酸的抗菌肽合成方法，国家发明专利，授权号ZL201810221262.9
2.于日磊、刘昊等，芋螺毒素复合物结构数据库软件，软件著作权，授权号2020SR0229866
3.于日磊、梁家珍，徐锡明，一种α-芋螺毒素Mr1.1及其突变体Mr1.1[I15L]，国家发明专利，专利号ZL201811402578.4